Sudikshaa Vijayakumar
Tagline:Predoctoral Fellow IIT Bombay | Postgraduate in Human Genetics | Publications on Cancer Drug Resistance and 3D Tumor Models
Chennai, Tamil Nadu, India
About Me
Hey, this is Sudikshaa Vijayakumar, from Chennai. A passionate researcher with a bachelor's in bioinformatics and a master's in Human Genetics. I recently completed my 1 year fellowship at IIT Bombay. Skilled in genomic data analysis and interpretation, machine learning tools, mammalian cell culture and PCR techniques, I thrive in collaborative environments where I can contribute to innovative research and projects.
Besides academics, I have a keen interest in various artworks. I like to sing as well.
Education
Master of Science
from: 2022, until: 2024Field of study:Human GeneticsSchool:Sri Ramachandra InstituteLocation:Chennai, India
Bachelor of Science
from: 2019, until: 2022Field of study:BioinformaticsSchool:Sri Ramachandra InstituteLocation:Chennai, India
Publications
“3D Aggregates of SiHa Cells”– Pathology- Research and Practice
Journal ArticlePublisher:Pathology - Research and PracticeDate:2025Authors:Sabari Krishnan B. B.Sudikshaa VijayakumarRaveena DhakshanamoorthyAkshaya BaskaranRavi MaddalyDescription:This study aims to investigate the morphology and morphometrics of agarose hydrogel-induced 3D aggregates of SiHa cell line.
Drug resistance in human cancers - Mechanisms and implications
ReviewPublisher:Life SciencesDate:2024Authors:Sudikshaa VijayakumarRaveena DhakshanamoorthyAkshaya BaskaranB. Sabari KrishnanRavi MaddalyDescription:We present here comprehensively the drug resistance in cancers along with their mechanisms. Also, apart from resistance to regularly used chemotherapeutic drugs, we present resistance induction to new generation therapeutic agents such as monoclonal antibodies. Finally, we have discussed the experimental approaches to understand the mechanisms underlying induction of drug resistance and potential ways to mitigate induced drug resistance.
Skills
Molecular Biology: PCR, Western Blot, Plasmid/DNA/RNA Isolation, Immunofluorescence, 3D Cell Culture
Cytogenetics: Karyotyping, FISH, PBLC, CVS, Amniotic Fluid Culture, Genetic Counseling
Observership Bioinformatics: Sequence Alignment (BLAST, CLUSTALW), UNIPROT, SWISSPROT, AutoDock Programming: R (statistical analysis, ML), HTML
Soft Skills: Scientific Writing, Communication, Team Collaboration
Languages Known: English, Tamil, Hindi
Work Experiences
Project Associate, IIT Bombay
from: 2024, until: 2025Organization:IIT BombayLocation:Mumbai, India
Description:- Project: Role of hybrid cancer stem cells in invasion
- Analyzed fluorescence intensity, motility, and nuclear/cytoplasmic ratio of MDA ACTN4 and OVOL2 cells using
ImageJ. - Assisted in generation of ACTN4-NLS and OVOL2-sh2 lines via LVP transfection and luciferase-tagged cell lines.
- Performed FACS sorting, Western blotting, and RT-PCR for gene/protein expression profiling.
Achievements
Predoctoral Fellow – NPTEL (Ministry of Education), 2024–2025
Subject Topper – 98% in CBSE English (Class XII, 2019)
Projects
Master’s Thesis (Mar – Jul 2024)
date: 2024Organization:Sri Ramachandra Institute
Description:- Investigated how low initial priming doses (LIPDs) of cisplatin and 5-FU influence cytotoxicity in HCT-116 colon cancer cells.
- Studied differential responses in 2D vs. 3D agarose-based cultures using the liquid overlay technique.
- Determined IC50 values and explored chemotherapy resistance in ex vivo tumor-like environments.
Bachelor’s Thesis (Mar – Jul 2022)
date: 2022Organization:Sri Ramachandra Institute
Description:- Built predictive models for hepatocellular carcinoma using gene expression data from the GEO database.
- Applied Lasso, Support Vector Machine, Multi-Layer Perceptron, and Random Forest algorithms in R.
- Compare model performances and interpreted gene significance in cancer prediction.